Presented by: Johns Hopkins School University of Medicine

Release Date: August 27, 2026                                                                  

Expiration Date: August 27, 2027

Estimated time to complete this activity: 4 hours and 30 minutes. This activity has been approved for a maximum of 4.5 AMA PRA Category 1 Credits™.

Fees and Prerequisites: There are no fees or prerequisites.

Acknowledgement of Commercial Support: Supported by an independent educational grant from Sanofi US.

Target Audience

This activity is intended to meet the educational needs of oncologists, urologists, and other members of the care team including APPs, pharmacists, nurses and fellows involved in the management of patients with mCRPC. Clinicians from community-based practices will be the focus of the initiative.

Learning Objectives

 After participating in this activity, learners will demonstrate the ability to:

• Apply evidence-based treatment sequencing strategies for mCRPC after ARPI progression, integrating prior treatment history, clinical disease characteristics, and biomarker results to select among available therapeutic options consistent with current national guidelines.
• Implement evidence-based toxicity monitoring and management protocols for later-line mCRPC therapies, including risk-stratified G-CSF prophylaxis, hematologic monitoring, and dose-optimization strategies.
• Employ structured shared decision-making frameworks to discuss later-line mCRPC treatment options with patients, communicating the expected benefits, risks, and quality-of-life implications of available therapies.

Presented by the Johns Hopkins University School of Medicine

Accreditation Statement

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of Johns Hopkins University School of Medicine and Medical Logix, LLC. The Johns Hopkins University School of Medicine is accredited by the ACCME to provide continuing medical education for physicians.

Credit Designation Statement 

The Johns Hopkins University School of Medicine designates this enduring material for a maximum of 4.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Other Credits

American Nurses Credentialing Center (ANCC) accepts AMA PRA Category 1 Credit™ from organizations accredited by the ACCME.

American Association of Nurse Practitioners National Certification Program accepts AMA PRA Category 1 Credit™ from organizations accredited by the ACCME.

American Academy of PAs (AAPA) accepts certificates of participation for educational activities certified for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME. PAs may receive a maximum of 4.5 AAPA Category 1 Credit for completing this program.

American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) Program

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 4.5 MOC points for Medical Knowledge + Practice Assessment in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

Policy on Presenter and Provider Disclosure

It is the policy of the Johns Hopkins University School of Medicine that the presenter and provider globally disclose conflicts of interest. The Johns Hopkins University School of Medicine OCME has established policies in place that will identify and mitigate relevant conflicts of interest prior to this educational activity. Detailed disclosure will be made prior to presentation of the education.

Statement of Need

Prostate cancer remains one of the most significant oncologic challenges in the United States, with an estimated 322,000 new cases projected in 2026 and approximately 3.4 million men currently living with the disease. Despite initial responses to androgen deprivation therapy, nearly all patients with metastatic disease will eventually progress to metastatic castration-resistant prostate cancer (mCRPC), with a median overall survival of approximately two years. The therapeutic landscape for mCRPC has expanded significantly over the past two decades. The very breadth of available agents has introduced substantial complexity into clinical decision-making, particularly when choosing second-line and later therapies. Clinicians now face the challenge of choosing among multiple agents with distinct mechanisms of action, different toxicity profiles, and varying levels of evidence in heavily pretreated populations. This educational initiative establishes impactful expert-led small group interactions among highly qualified community oncologists, urologists, APPs, nurses, pharmacists, fellows, and other members of the care team involved in the treatment of patients with mCRPC that will, through a variety of collaborative educational experiences, help them optimize the care provided to these patients.

Format and Method of Participation

Review this enduring CME activity. To take the post-test, please click on the post-test button below the video window of the player which will take you to the Johns Hopkins School of Medicine’s website. If you already have registered for other programs at this website, simply enter the requested information when prompted. Otherwise, complete the registration form to begin the testing process. The information you enter here will be used to generate your CME certificate. Please complete all fields to ensure accurate registration. Complete the post-test and evaluation and attest to the amount of time spent in the activity. Upon receiving a score of 70% or above, print your CME certificate.

Full Disclosure Policy Affecting CME Activities

As a provider approved by the Accreditation Council for Continuing Medical Education (ACCME), Johns Hopkins School of Medicine Office of Continuing Medical Education (OCME) requires attested and signed global disclosure of the existence of all financial interests or relationships with ineligible companies from any individual in a position to control the content of a CME activity sponsored by OCME.

Faculty

No one else in a position to control the content of this educational activity has disclosed a relevant financial interest or relationship with an ineligible company. All relevant conflicts of interest have been mitigated prior to the commencement of the activity.

Note: Grants to investigators at The Johns Hopkins University are negotiated and administered by the institution which receives the grants, typically through the Office of Research Administration. Individual investigators who participate in the sponsored project(s) are not directly compensated by the sponsor, but may receive salary or other support from the institution to support their effort on the project(s).

Johns Hopkins Statement of Responsibility

The Johns Hopkins School of Medicine takes responsibility for the content, quality, and scientific integrity of this CME activity.

Copyright

All rights reserved - The Johns Hopkins School of Medicine. No part of this program may be used or reproduced in any manner whatsoever without written permission except in the case of brief quotations embodied in articles or reviews.

Internet CME Policy

The Office of Continuing Medical Education (OCME) at the Johns Hopkins School of Medicine is committed to protecting the privacy of its members and customers. Johns Hopkins School of Medicine OCME maintains its Internet site as an information resource and service for physicians, other health professionals and the public. OCME at the Johns Hopkins School of Medicine will keep your personal and credit information confidential when you participate in a CME enduring program. Your information will never be given to anyone outside of the Johns Hopkins School of Medicine CME program. CME collects only the information necessary to provide you with the services that you request.

What you should know about gifts to physicians from industry

Gift giving from the pharmaceutical, device and medical equipment industries to physicians has long been a customary practice. But when gift giving is not practiced within established ethical boundaries, the perception of conflict of interest is raised. All physicians and physicians in training should adhere to the AMA Code of Medical Ethics, Opinion 8.061, “Gifts to Physicians from Industry” which can be found under the AMA Code of Medical Ethics at https://code-medical-ethics.ama-assn.org/ethics-opinions/gifts-physicians-industry.

Johns Hopkins faculty, staff, employees, students, and trainees must adhere to the more restrictive Johns Hopkins Medicine Policy on Interaction with Industry that can be found at this link https://industryinteraction.jhu.edu/jhm-policy-on-interaction-with-industry.

Disclaimer

The opinions and recommendations expressed by faculty and other experts, whose input is included in this program are their own. This enduring material is produced for educational purposes only. Use of the Johns Hopkins School of Medicine name implies review of educational format design and approach. Please review the complete prescribing information of specific drugs or combinations of drugs, including indications, contraindications, warnings and adverse effects before administering pharmacologic therapy to patients.

AMERICANS WITH DISABILITIES ACT

The Johns Hopkins School of Medicine fully complies with the legal requirements of the ADA and the rules and regulations thereof. Please notify us if you have any special needs.

Course Format – Method of Participation

This enduring material is expected to take approximately 4.5 hours to complete. Once the activity is completed, you must pass the post-test and complete the evaluation with attestation to receive CME credit.

POST-TEST
A post-test will be conducted at the conclusion of the activity. A grade of at least 70% within three attempts is needed to receive CME credit.

FACULTY

Catherine Handy Marshall, MD, MPH
Associate Professor of Oncology
Johns Hopkins School of Medicine
Baltimore, MD

Adel Mandl, MD, PhD
Assistant Professor of Oncology
Johns Hopkins School of Medicine
Baltimore, MD

Off-Label Discussion

There are no references to off-label/unapproved uses of products in this program.

Confidentiality Disclaimer for CME Activity Participant

I certify that I am participating in this Johns Hopkins School of Medicine activity for CME-accredited training and/or educational purposes.

I understand that while I am participating in this capacity, I may be exposed to "protected health information," as that term is defined and used in Hopkins policies and in the federal HIPAA privacy regulations (the “Privacy Regulations”). Protected health information is information about a person's health or treatment that identifies the person.

I pledge and agree to use and disclose any of this protected health information only for the training and/or educational purposes of my visit and to keep the information confidential. I agree not to post or discuss this protected health information, including pictures and/or videos, on any social media site (eg, Facebook, Twitter, etc.), in any electronic messaging program or through any portable electronic device.

I understand that I may direct to the Johns Hopkins Privacy Officer any questions I have about my obligations under this Confidentiality Pledge or under any of the Hopkins policies and procedures and applicable laws and regulations related to confidentiality. The contact information is:  Johns Hopkins Privacy Officer, telephone: 410-614-9900, e-mail: HIPAA@jhmi.edu.

“The Office of Continuing Medical Education at the Johns Hopkins School of Medicine, as sponsor of this activity, has relayed information with the CME attendees/participants and certify that the visitor is here for training, education and/or observation purposes only.”

For CME questions, please contact the CME Office 410-955-2959 or email cmenet@jhmi.edu.

For CME Certificates, please call (410) 502-9636.

Johns Hopkins School of Medicine
Office of Continuing Medical Education
720 Rutland Avenue/ Turner 20
Baltimore, Maryland 21205-2195
Reviewed & Approved by: General Counsel, Johns Hopkins Medicine (4/1/03)
(Updated 4/09 and 3/14)